2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-E70305
    GlcNAc-1-Phosphotransferase 84012-69-1 98%
    GlcNAc-1-Phosphotransferase is an α2β2γ2 hexamer with core catalytic α- and β-subunits derived from GNPTAB. GlcNAc-1-Phosphotransferase catalyzes the addition of the il group of N-acetylglucosamine-1-phosphate to the terminal mannose. Mutations in GlcNAc-1-Phosphotransferase cause lysosomal storage disorders such as mucolipidosis.
    GlcNAc-1-Phosphotransferase
  • HY-E70395
    Prolyl endopeptidase 72162-84-6 98%
    Prolyl Endopeptidase, highly active in brain and other tissues, catabolizes proline-containing peptides such as substance P, neurotensin, luteinizing hormone-releasing hormone, thyrotropin releasing hormone, bradykinin and angiotensin II. Prolyl Endopeptidase can be used for study of neuropsychiatric diseases such as stress disorder, depression, and schizophrenia.
    Prolyl endopeptidase
  • HY-E70410
    NAD Synthetase 9032-69-3 98%
    NAD synthetase is responsible for the final step in the synthesis of nicotinamide adenine dinucleotide (NAD). The Km values for NAD, ATP, and ammonia of NAD synthetase from Escherichia coli are 200 μM, 11 μM, and 0.65 μM, respectively, while the Km values for NAD, ATP, and ammonia of NAD synthetase from yeast are 170 μM, 190 μM, and 64 μM, respectively. NAD synthetase can be used for enzymatic assays to determine ATP, ammonia, urea, or creatinine, and is also suitable for enzymatic cycling methods. Additionally, NAD synthetase holds potential for research into metabolic diseases, cancer, aging, and neurodegenerative diseases.
    NAD Synthetase
  • HY-E70514
    Human CYP26B1,Low-Reductase 98%
    Human CYP26B1, Low-Reductase, a recombinant CYP26B, is a member of the CYP enzyme family. CYP26B1 is important for the development and differentiation of the central nervous system (especially the hindbrain) and skeletal development.
    Human CYP26B1,Low-Reductase
  • HY-ER013I
    Sodium carbonate anhydrous, meets analytical specification of Ph. Eur., BP, NF, FCC, E500 497-19-8 98%
    Sodium carbonate anhydrous, meets analytical specification of Ph. Eur., BP, NF, FCC, E500 is a biochemical assay reagent suitable for buffer configuration.
    Sodium carbonate anhydrous, meets analytical specification of Ph. Eur., BP, NF, FCC, E500
  • HY-G0001S
    Lurasidone Metabolite 14283-d8 2070009-43-5 98%
    Lurasidone Metabolite 14283-d8 is the deuterium labeled Lurasidone Metabolite 14283, which is a metabolite of Lurasidone.
    Lurasidone Metabolite 14283-d8
  • HY-G0002S
    Lurasidone Metabolite 14326-d8 98%
    Lurasidone Metabolite 14326-d8 is the deuterium labeled Lurasidone Metabolite 14326, which is a metabolite of Lurasidone.
    Lurasidone Metabolite 14326-d8
  • HY-G0014S
    Quetiapine Sulfoxide-d8 1330238-38-4 98%
    Quetiapine Sulfoxide-d8 is the deuterium labeled Quetiapine sulfoxide. Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.
    Quetiapine Sulfoxide-d8
  • HY-I0096S
    Indole-2-carboxylic acid-13C 1216839-31-4 98%
    Indole-2-carboxylic acid-13C is the 13C-labeled Indole-2-carboxylic acid. Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Indole-2-carboxylic acid (I2CA) specifically and competitively inhibits the potentiation by glycine of NMDA-gated current.
    Indole-2-carboxylic acid-13C
  • HY-I0230S
    Solifenacin-d7 hydrochloride 98%
    Solifenacin-d7 (hydrochloride) is the deuterium labeled Solifenacin hydrochloride. Solifenacin hydrochloride (YM905 hydrochloride) is a muscarinic receptor antagonist, with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.
    Solifenacin-d7 hydrochloride
  • HY-I0637R
    Isovanillin (Standard) 621-59-0
    Isovanillin (Standard) is the analytical standard of Isovanillin. This product is intended for research and analytical applications. Isovanillin is an aldehyde oxidase inhibitor. Antispasmodic activities. Antidiarrheal activities.
    Isovanillin (Standard)
  • HY-I0746R
    3-Aminobenzoic acid (Standard) 99-05-8
    3-Aminobenzoic acid (Standard) is the analytical standard of 3-Aminobenzoic acid. This product is intended for research and analytical applications. 3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent targeting the tight junction (TJ) regulatory pathways in intestinal epithelial cells. 3-Aminobenzoic acid improves intestinal inflammation by enhancing intestinal barrier integrity and reducing epithelial permeability. It can be used in studies related to improving gut health. Additionally, 3-Aminobenzoic acid analogs can act as γ-aminobutyric acid transaminase (GABA-AT) inhibitors, exhibiting anticonvulsant effects.
    3-Aminobenzoic acid (Standard)
  • HY-N0006R
    Demethoxycurcumin (Standard) 22608-11-3
    Demethoxycurcumin (Standard) is the analytical standard of Demethoxycurcumin. This product is intended for research and analytical applications. Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research.
    Demethoxycurcumin (Standard)
  • HY-N0008R
    Orcinol glucoside (Standard) 21082-33-7
    Orcinol glucoside (Standard) is the analytical standard of Orcinol glucoside. This product is intended for research and analytical applications. Orcinol glucoside (OG) is an active constituent isolated from Curculigo orchioides, with antidepressant effects. Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway.
    Orcinol glucoside (Standard)
  • HY-N0009R
    Geniposide (Standard) 24512-63-8
    Geniposide (Standard) is the analytical standard of Geniposide. This product is intended for research and analytical applications. Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.
    Geniposide (Standard)
  • HY-N0013R
    Vitexin (Standard) 3681-93-4
    Vitexin (Standard) is the analytical standard of Vitexin. This product is intended for research and analytical applications. Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects.
    Vitexin (Standard)
  • HY-N0020R
    Echinacoside (Standard) 82854-37-3
    Echinacoside (Standard) is the analytical standard of Echinacoside. This product is intended for research and analytical applications. Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche deserticola, effectively inhibits Wnt/β-catenin signaling. Echinacoside elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Antiosteoporotic activity.
    Echinacoside (Standard)
  • HY-N0021R
    Verbascoside (Standard) 61276-17-3
    Verbascoside (Standard) is the analytical standard of Verbascoside. This product is intended for research and analytical applications. Verbascoside is isolated from Acanthus mollis, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 μM, and has antitumor, anti-inflammatory and antineuropathic pain activity.
    Verbascoside (Standard)
  • HY-N0035R
    Arctigenin (Standard) 7770-78-7
    Arctigenin (Standard) is the analytical standard of Arctigenin. This product is intended for research and analytical applications. Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions.
    Arctigenin (Standard)
  • HY-N0042R
    Ginsenoside Rc (Standard) 11021-14-0
    Ginsenoside Rc (Standard) is the analytical standard of Ginsenoside Rc. This product is intended for research and analytical applications. Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β.
    Ginsenoside Rc (Standard)
Cat. No. Product Name / Synonyms Application Reactivity